Homo sapiens

UniProt Data

Accession P62993 [ UniProt ]
Name GRB2_HUMAN
Description Adapter protein GRB2
Species Homo sapiens
Sequence Length217

Enzyme Annotations (0)

    GO Annotations

    Cellular component (1)

    None predicted

    Molecular function (3)

    • GO:0005070 SH3/SH2 adaptor activity
      Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
    • GO:0005154 Epidermal growth factor receptor binding
      Interacting selectively and non-covalently with the epidermal growth factor receptor.
    • GO:0043560 Insulin receptor substrate binding
      Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. [PMID:12829233]

    Biological process (16)

    • GO:0007173 Epidermal growth factor receptor signaling pathway
      The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
    • GO:0007265 Ras protein signal transduction
      A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
    • GO:0007267 Cell-cell signaling
      Any process that mediates the transfer of information from one cell to another.
    • GO:0007411 Axon guidance
      The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
    • GO:0007596 Blood coagulation
      The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [http://www.graylab.ac.uk/omd/, ISBN:0198506732 Oxford Dictionary of Biochemistry and Molecular Biology]
    • GO:0008286 Insulin receptor signaling pathway
      The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
    • GO:0008543 Fibroblast growth factor receptor signaling pathway
      The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
    • GO:0010670 Positive regulation of oxygen and reactive oxygen species metabolic process
      OBSOLETE. Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH).
    • GO:0031295 T cell costimulation
      The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. [ISBN:0781735149 Fundamental Immunology]
    • GO:0031623 Receptor internalization
      A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
    • GO:0034329 Cell junction assembly
      A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.
    • GO:0042059 Negative regulation of epidermal growth factor receptor signaling pathway
      Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
    • GO:0042770 Signal transduction in response to DNA damage
      A cascade of processes induced by the detection of DNA damage within a cell.
    • GO:0048011 Nerve growth factor receptor signaling pathway
      The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands.
    • GO:0050900 Leukocyte migration
      The movement of a leukocyte within or between different tissues and organs of the body.
    • GO:0071479 Cellular response to ionizing radiation
      Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.

    Protein Sequence

    >P62993
    MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHD
    GAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTY
    VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV