Structural predictions using pDomTHREADER and PSI-BLAST using CATH domains and the PDB
DomSerf is a fully automated, protein-domain homology modelling process combining pDomTHREADER, PSI-BLAST, DomainFinder and MODELLER. Input sequences are first matched to a library of CATH Superfamilies by both pDomTHREADER and PSI-BLAST. These results are then used by DomainFinder to resolve the best scoring set of domains which cover the greatest amount of the input sequence, with minimal overlap. Finally, with a minimal set of good superfamily alignments in hand, MODELLER is used to build a model for each identified domain.
Group Leader:David Jones