Alexey Murzin Laboratory of Molecular Biology, Cambridge

SCOP

SCOP is a database of relationships amongst proteins of known structure. Like the Linnaean taxonomy, it groups hierarchically protein domains by their near and far homology and structural similarity.

Christine Orengo University College London

Gene3D

Gene3D provides predicted CATH structural domain annotations for major protein sequence databases and sequence genomes using an accurate and sensitive automated homologue recognition protocol.

CATH

CATH provides information on protein structures that are related by evolution. Protein structures (from the PDB) are chopped into structural domains then grouped into evolutionary superfamilies.

David Jones University College London

pDomTHREADER

Protein fold predictions using pDomTHREADER based on the CATH domain library

DomSerf

Structural predictions using pDomTHREADER and PSI-BLAST using CATH domains and the PDB

Julian Gough University of Bristol

SUPERFAMILY

The SUPERFAMILY database provides SCOP structural domain annotation of protein sequences at the superfamily and family levels using a library of HMMs.

Michael J E Sternberg, Lawrence A Kelley Imperial College London

PHYRE2

Phyre2 - Protein Homology/analogY Recognition Engine V 2.0 Webserver for protein structure prediction based on SCOP and PDB, and HMM-HMM alignment techniques for remote homology detection.

Tom L Blundell Cambridge University

FUGUE (CATH-based)

Homology recognition using environment-specific substitution tables and structure-dependent gap penalties against the TOCCATA database of annotated structural profiles based on SCOP and CATH.

FUGUE (SCOP-based)

Homology recognition using environment-specific substitution tables and structure-dependent gap penalties against the TOCCATA database of annotated structural profiles based on SCOP and CATH.

VIVACE

Comparative modelling pipeline based on FUGUE, TOCCATA and MODELLER employing conformation-sensitive multiple template selection.